Southbound International Medical Collaboration and Sharing of Academic Research Experience
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        From Ho Chi Minh City Children’s Hospital No.1 & No.2 to Ho Chi Minh City Children’s Hospital

        The world-renowned dengue fever virus research expert, Dr. Scott B. Halstead, visited NCKU on March 16, 2001. At the time, he was President of American Bureau for Medical Advancement in China (ABMAC). More importantly, he created the antibody-dependent enhancement theory of dengue hemorrhagic fever pathogenesis. He was highly respected in the field of international dengue fever research. In addition to visiting NCKU Medical Center as a representative of ABMAC, another mission of his was to host a table talk with the NCKU researchers of dengue fever virus infection.

        In January the doctors from Ho Chi Minh City Children’s Hospital No.1 visited NCKU Hospital to discuss collaborative training (Photo 5), which then brought the Hospital's team of pediatric cardiologists and cardiac surgeons to NCKU in Tainan for a 6-month intensive training for open-heart surgery. As a result of the training, open-heart surgery success rate increased and thus far the Hospital has completed thousands of cases of pediatric heart surgery.

        With the leadership and sponsorship of the clinical team of National Health Research Institutes (NHRI), NCKU added VAHS caused by EBV to the scope of research, in addition to the research of dengue hemorrhagic fever pathogenesis. In addition, research of serious illness clinical treatment of Enterovirus 71, and traineing of local talents for the clinical virus labs was inititated. This was a 3-year international collaborative research program among NHRI, NCKU, and Vietnam, which lasted a total of 6 years in 2 phases. Ho Chi Minh City Children’s Hospital No.1 celebrated its completion in a ceremony on November 11, 2009, permitting the ability of virus isolation and cultivation. The findings of the clinical trial treatment of Enterovirus 71 serious illness has been published on Critical Care Medicine (2013;41(7):1754-60) in July, 2013.

        The government hopes to further bilateral exchange and collaboration of political and economic culture and education. The southbound international collaborative has become a new trend for every research-oriented university. However, the method of promotion and support to achieve the desired result of collaborative research is never easy. One way is to mimic how Oxford University copes with the Hospital for Tropical Diseases in Ho Chi Minh City is the right path for us to take root from.


        2001年3月16日國際級登革病毒研究大師Dr. Scott B. Halstead 到成大參訪,他當時是「美國在華醫藥促進局」(American B u r e a u f o r M e d i c a l A d v a n c e m e n t i n China, ABMAC) 會長,更重要的是他為登革出血熱致病機轉“ 抗體依賴增強”(antibody-dependent enhancement, ADE)理論的創始者,在國際登革熱研究具有崇高地位。到成大醫學院除了代表ABMAC 訪查外,另外就是和成大登革病毒感染研究群座談,並且幫忙牽線促成與越南胡志明市第一兒童醫院合作研究登革出血熱致病機轉。

        2005年元月越南第一兒童醫院醫師拜訪成大醫院洽談合作訓練事宜( 圖五),促成後來第一兒童醫院小兒心臟科和心臟外科團隊到台南成大醫院接受為期6個月的開心手術相關訓練,終於成功開展該院的小兒開心手術,目前已成功完成數千例的小兒心臟手術。

        在國家衛生研究院臨床組主導及經費贊助下,除了登革出血熱致病機轉研究外,我們增加了EBV病毒感染導致病毒吞噬症候群(VAHS) 的研究,及腸病毒71 型重症臨床治療的前瞻性研究和培訓當地臨床病毒室人才,此為國衛院、成大和越南合作的3年國際合作研究計畫,前後共兩期6年。2009年11月11日胡志明市第一兒童醫院病毒室落成紀念,開啟後續兒童醫院病毒分離培養的能力,也為後續腸病毒臨床試驗鋪路。腸病毒71型重症使用Milrilone 治療的3年臨床試驗成果,已發表於2013年7 月Critical Care Medicine (Crit Care Med 2013;41(7):1754-60.)。