Microalgae Biorefinery and Circular Economy Team
微藻生物煉製與循環經濟團隊
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          A circular economy is presented as a system of resource utilization where reduction, reuse and recycling of elements prevails. Furthermore, production is limited to a bare minimum and when it's necessary to use the product, attempt to reuse elements that cannot return to the environment. The potential of using algae to remediate waste, including nutrients, metal, carbon dioxide and organic pollutants, has been recognized for many decades. Prof. Jo-Shu Chang has a wide collection of microalgae and is the world-leading expert in microalgal research, currently ranking #1 in the world for publications in the area of both “microalgae” and “microalgal biofuels” (according to Web of Science). He and Dr. Chun-Yen Chen are founders of National Cheng Kung University (NCKU)’s “Center for Microalgae Biotechnology and Engineering.” The NCKU’s microalgae team has state-of-the-art technology for production of microalgae-based biofuels and chemicals, as well as flue gas CO2 reduction and utilization. The team has developed innovative and effective photobioreactor technology to convert CO2 into feed, health food and fuels via integration of microalgae isolation, cultivation system design and harvesting techniques for downstream technology. Furthermore, they also established core technologies for microalgae-based wastewater treatment and application of specific microalgae as a feed supplement for grouper and shrimp. The NCKU microalgae team has also constructed a commercial-scale microalgae cultivation & biorefinery plant located at NCKU’s An-Nan Campus. Prof. Chang is the leading PI of the national energy project of Taiwan, working on microalgae-based biofuels production and CO2 re-utilization from 2009-2018. Prof. Chang and his team also developed Asia’s first pilot demonstration system for direct use of flue-gas from a steel-making factory to cultivate microalgae. He has established platform technologies for re-utilization of CO2 via a phototrophic microalgal carbon capture systems, as well as a microalgae-driven circular economy. Associate Prof. I-Son Grace Ng is devoted to synthetic biology, genetic and enzymatic engineering as applied in bioenergy and biorefinery. She has been working with several top researchers in the areas of biofuel, biorefinery and bioremediation to develop a robust and efficient approach using genetic and proteomic techniques to explore novel and functional enzymes of microorganisms. Furthermore, she developed protocols to apply CRISPR/Cas9 techniques on green algae, creating novel opportunitie.

          循環經濟是一種資源利用系統,其中元素的減少,再利用和再循環占主導地位:將生產降至最低,並且當需要使用產品時,重新使用不能返回環境的元素。也就是說,循環經濟促進在產品製造中使用盡可能多的可生物降解材料,因此它們可以回歸自然而不會在其使用壽命結束時造成環境破壞。幾十年來,人們已經認識到使用藻類來補救廢物(包括養分,金屬,二氧化碳和有機污染物)的潛力。威廉·奧斯瓦爾德(William Oswald)在20世紀50年代開創的工作確立了微藻在生活污水處理中的潛力。美國的安全能源驅動力促成了國家可再生能源實驗室的生物燃料計劃和水生物種計劃。該項目對微藻進行脂質篩選和培養,為進一步研究奠定了基礎。再加上21世紀初可再生能源生產的重新推動,最終形成了一系列路線圖。

          張嘉修教授收集了廣泛的微藻株,是世界領先的微藻研究專家,目前他在“微藻”和“微藻生物燃料”領域的出版量排名世界前列(根據Web of Science)。他和陳俊延博士是國立成功大學的“微藻生物技術與工程中心”的創始人。國立成功大學的微藻團隊擁有最先進的技術,可用於基於微藻的生物燃料和化學品生產以及煙氣二氧化碳減排和利用。該團隊還開發了創新和有效的光生物反應器技術,通過整合微藻分離,培養系統設計,收穫技術和其他下游技術,將二氧化碳轉化為飼料,保健食品和燃料。此外,該團隊還建立了基於微藻的廢水處理和特定微藻的應用核心技術,作為石斑魚和蝦養殖的飼料添加劑。國立成功大學微藻團隊還在安南校區建造了一個商業規模的微藻養殖和生物精煉工廠。張教授是台灣國家能源計畫的領導者,致力於2009 - 2018年期間基於微藻的生物燃料生產和二氧化碳再利用。最近,張教授將他的研究興趣轉移到使用微藻進行廢水處理和水產養殖。張教授和他的團隊還開發了亞洲第一個直接使用煉鋼廠煙氣培養微藻的試驗示範系統。他建立了一個通過光自營微藻碳捕獲系統以及利用微藻驅動的循環經濟來重新利用二氧化碳的技術平台。他的許多關鍵技術已成功技轉至產業界,其中一些已經商業化。吳意珣副教授致力於合成生物學,遺傳學和酶學工程,應用於生物能和生物精煉。她一直與生物燃料,生物精煉和生物修復領域的幾位頂尖研究人員合作,開發出一種強大而有效的方法,通過微生物的遺傳和蛋白質組學探索新型和功能性酶。此外,她開發了將CRISPR/Cas9技術應用於綠藻的方案,包括用於基因下調的CRISPRi,用於激活基因上調的CRISPRa和用於無標記基因組編輯的Cas9-RNP。