Known as “the grouper kingdom,” Taiwan ranks 1st in the world with annual grouper production, creating revenue of more than NT$8 billion annually. Recently however, there have been frequent outbreaks of highly contagious and fatal grouper virus infection. If just one grouper is infected, a large number of grouper will die very quickly, causing significant monetary losses to the industry. In 2018, Professor Jiann-Ruey Hong (Department of Biotechnology and Bioindustry Sciences) developed a combination treatment of functional additives. Through autophagy inhibition, virus reproduction can be effectively reduced, and virulence can be reduced more than 100-fold improving cell survival and increasing fish growth rate from 30% to 50%.