Enterovirus Study and Prevention
腸病毒研究與防治
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          The World Now Sees the Hard Work of the Enterovirus Team from NCKU Medical Center.

          In the past decade, a research group from NCKU Medical Center conducted a series of studies on the pathogenesis, virology, and clinical treatment of Enterovirus,

          becoming the main research group of this field in the world. Led by Professor Ching-Chuan Liu, the main members of NCKU’s research group include Dr. Shih-Min Wang, Professor Huan-Yao Lei, Professor Ih-Jen Su, Professor Jen-Ren Wang, Professor Chun-Keung Yu, and others. They have published over 50 articles in international journals since 1988. Among the members, Professors Ching-Chuan Liu, Chao-Ching Huang and Jen-Ren Wang are world-leading authors for the New England Journal of Medicine. NCKU Medical Center— An Ambassador of Taiwan Public Heath to be Proud of.

          For many years now NCKU's Enterovirus team is an active participant in international affairs, including the APEC Enterovirus Seminar, clinical experience sharing in Vietnam, guideline development for the diagnosis and medical treatment, establishing bilateral research collaboration plans, training Vietnamese clinical doctors and research assistants on virus cultivation, and assisting in setting up local virus cultivation laboratories. The team clinically tested a treatment for pulmonary edema caused by Enterovirus 71. The test found the death rate of treated patients dropped significantly. This important finding helps establish the guidelines for serious illness treatment of Enterovirus.

          Additionally, the team attended international conferences held in the U.S., China, India, and South Korea to share their clinical experience. Together with representatives from the West Pacific Region, including Singapore, Malaysia, Australia and Vietnam, the team formulated WTO's guidelines for diagnosing and treating hand, foot, and mouth disease, and organized international seminars. Nearly 30% of the research papers quoted by the clinical standard treatment section of WTO’s guidelines are written by the team at NCKU Medical Center. NCKU is honored by the team’s achievement and this academic strength is illustrious.

          Received National Biotechnology and Medical Quality Award Bronze Award for Medical Specialty— Protecting Children's Health. The Enterovirus medical care team in the department of pediatrics competed by entering the “Outstanding Enterovirus Team— From Virus Confirmation to Clinical Treatment and Experience Sharing” lecture contest. They were successful against many strong competitors and won the Bronze Award for Medical Specialty under National Biotechnology and Medical Quality Award, also dubbed as the Taiwan medical Oscar. Their achievements in medical care were recorded in TOP Medical Treatment in Taiwan (ISBN:9789868015050), a social recognition for NCKU Medical Center’s ongoing endeavors in Children health care maintenance, treatment and care.

          Primary Achievements of the Enterovirus team of NCKU Medical Center for the past decade

          * First confirmed brainstem as the organ of infection target for Enterovirus 71.

          * Formulated clinical grading for Enterovirus 71 type brainstem encephalitis.

          * Confirmed the features and trend of epidemiology for Enterovirus 71 infection.

          * Confirmed that the pathogenesis of cytokine and its cellular immunity are involved in Enterovirus 71 type brainstem encephalitis.

          * Established the treatment for serious illness complicated by Enterovirus 71 type brainstem. 

          成大醫學中心腸病毒團隊的努力,讓全世界看到了

          過去十多年來,成大醫學中心研究團隊針對致病機制、病毒學以及臨床處置進行系列研究,已成為世界上此領域的主要研究群。成大研究團隊在劉清泉教授的領導下,主要成員包括王世敏醫師、黎煥耀教授、蘇益仁教授、王貞仁教授、余俊強教授等人,自1998 年至今亦發表超過五十篇國際期刊論文。而其中劉清泉教授、黃朝慶教授與王貞仁教授更是名列於世界首屈一指新英格蘭醫學雜誌(New England Journal of Medicine)的作者。

          成大醫學中心―令人驕傲的台灣公衛大使

          多年來成大腸病毒團隊積極參與國際事務,包括參加亞太經合會(APEC) 舉辦之腸病毒研討會,赴越南進行臨床經驗分享,制訂診斷與治療準則,建立雙邊研究合作計畫,訓練越南臨床醫師及研究助理病毒培養檢驗技術,協助當地病毒培養實驗室之建立。並進行Milrinone 治療腸病毒71 型引發肺水腫的臨床試驗,發現治療病患的死亡率顯著降低。此結果對於確立腸病毒重症治療的準則有相當大的幫助。

          外並赴美國、中國、印度、韓國國際會議分享臨床經驗。並和西太平洋地區國家新加坡、馬來西亞、澳洲、越南等國代表共同制定世界衛生組織手足口症診斷與治療準則,籌辦國際研討會。在世界衛生組織準則中,臨床標準處置部份所引用的研究論文,近三成來自成大醫學中心團隊,這種難被忽視的學術實力,著實令人感到驕傲。

          榮獲2010國家生技醫療品質獎

          醫院特色專科組銅獎 持續守護兒童健康

          小兒部腸病毒照護團隊更於2010 年以「卓越腸病毒團隊: 從病毒確認到臨床診治與社會分享」為主題,在強敵環伺下勇奪號稱台灣醫界奧斯卡獎- 國家生技醫療品質獎醫院特色專科組銅獎,照護成果更獲『TOP 醫療在台灣』(ISBN:9789868015050) 一書收錄,代表社會各界對成大醫院兒童健康維護、治療與照護持續努力之肯定。

          成大醫學中心腸病毒團隊十多年來的主要成就

          * 首先確認腦幹為腸病毒71 型感染之標的器官

          * 訂定腸病毒71 型腦幹腦炎之臨床分級

          * 確認腸病毒71 型感染之流行病學表徵與趨勢

          * 確認細胞激素致病機轉與其細胞免疫力參與腸病毒71 型腦幹腦

          * 建立腸病毒71 型腦幹腦炎併發重症之治療方式

          * 確認腸病毒71 型腦幹腦炎病童長期認知與運動功能之癒後追蹤

          * 建立腸病毒71 型感染動物模式以進行致病機轉與治療方式研究

          * 發現小鼠動物模式中確認減毒腸病毒71 型與科沙奇A16 型之免疫力可預防腸病毒71 型感染

          * 完成1998-2008 年間台灣腸病毒71 型基因與抗原性演變之動態分析

          * 與越南建立國際合作腸病毒71 型研究計畫