A Critical Medical Defense Against Dengue Fever in Southern Taiwan— the NCKU Medical Center
南臺灣防蚊抗登革的醫療重鎮:成大醫院
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          NCKU Medical Center’s Research Findings

          NCKU Hospital maintained its duty of guarding public health against multiple waves of dengue fever. NCKU Hospital is a wealth of clinical experience in dengue fever prevention, treatment and care. It joined forces with the dengue fever research team to continue devotion for clinical research and the study of dengue fever virus.

          Let’s look at the research progression of NCKU Medical Center in the past decade from two books on dengue fever. The book on the left is Dengue Disease (ISBN 978-81-308-0290-9) written in 2008 by Professor Huan-Yao Lei from the Department of Microbiology & Immunology of NCKU. This was the first English textbook on dengue fever in Taiwan. The co-authors were Director Ching-Chuan Liu, Dr. Shih-Min Wang, and other experts. It represents the contribution by NCKU towards dengue fever research from 1996 to 2008. Furthermore, 11 articles in the dengue fever featured issue of American Journal of Infectious Disease (Jan. Issue) were contributed by the dengue fever research group of NCKU Medical Center. Subsequently, the group published six journals in the dengue fever featured issue of Journal of Biomedical Science in 2013, of which 5 articles were listed as highly accessed papers.

          The book on the right is Taiwan Experience with Dengue Fever: From epidemiology and Clinical Treatment to the New Horizon of Basic Science (ISBN 978-986-04-8675-9) written by Yee-Shin Lin of the Department of Microbiology & Immunology. It was the first popular Chinese science book on dengue fever. The co-authors were Director Ching-Chuan Liu, Dr. Tzong-Shiann Ho, and others. The book simplifies the intricate illness state of dengue fever and the guidelines for handling. These were developed into a seven-word poem which, in literal translation, is “2 waves of fever in 6 days; The rash follows the endangering fever; Blood test within the first 5 days of virus infection; In dengue fever exists tricks to conquer it; Refrain from overdose of fluid transfusion; No blood transfusion unless it is necessary; The body fluid will be re-absorbed.”

          In 2014, the group was invited to write an electronic textbook named “Dengue fever: transmission, diagnosis & surveillance”, edited by Jamie Whitehorn and Jeremy Farrar, Future Medicine Ltd. (ISBN: 978-1-78084-384-1). Chapter title: “Lessons learned from dengue – Focus on Taiwan”, which introduced Taiwan's experience to the world's related clinical personnel and research workers. In 2011, the Center of Infectious Disease and Signaling Research was founded and members include clinical and basic infectious disease experts from NCKU. In recent years the group formed a long-term collaboration with medical and research institutes in dengue-fever-afflicted Southeast Asian countries such as Thailand, Vietnam, Malaysia, Singapore and Sri Lanka.

          In 2017, the dengue fever research group of NCKU held a workshop of emerging and re-emerging infectious diseases, inviting dengue fever scholars from Southeast Asia to convene at NCKU. Through multi-lateral sharing of research findings, the workshop matched invited scholars with Taiwanese scholars for epidemiology, intensive care, pathogenesis, anti-virus medication and vaccine optimization to establish bilateral or multi-lateral collaboration. Southeast Asia Dengue Fever Research Institute was founded upon this concept to foster the establishment of Southeast Asia Dengue Fever Research Platform.

          In the future the group will utilize the accumulated findings of fundamental research, the college’s and the world's perspectives, and continue the clinical study of dengue fever virus, fundamental research, and the R&D of vaccines and medications. By analyzing the epidemiology of dengue fever in Southern Taiwan, the group will improve the efficacy of medical care, actively cultivate new-generation talents with a passion for dengue fever research, and operate the Southeast Asia Dengue Fever Research Platform to provide prevention strategies and preparations against future dengue fever outbreaks.

          成大醫院在歷次登革熱流行,均肩負守護民眾健康天職,不但累積登革熱預防、治療及照護臨床經驗,亦和成大醫學院登革研究團隊並肩作戰,持續致力於登革熱臨床和登革病毒研究。

          就從兩本登革專書談起成醫十年來的登革研究進展。左邊是2008年成大醫學院微免所黎煥耀教授主編的 「Dengue Disease」(ISBN 978-81-308-0290-9),是台灣第一本登革熱英文教科書,共同作者包括本院劉清泉主任、王世敏醫師等專家,它代表1996-2008年間成醫登革研究的貢獻。此外,2008年1月美國感染症期刊(American Journal of Infectious Disease) 登革專輯內11篇文章,均來自成醫登革研究群。嗣後2013 年生物醫學期刊(Journal of Biomedical Science)登革特輯,發表六篇期刊論文,其中五篇被列為高度點閱文章 (highly accessed papers)。右邊是2016 年微免所林以行教授主編的「登革熱的台灣經驗:從流行病學及臨床到基礎科學的新視野」 (ISBN 978-986-04-8675-9),是第一本中文科普登革專書,共同作者包括本院劉清泉主任、何宗憲醫師等;將登革熱複雜病情變化及處置要領,簡化為一首七言律詩『登革熱心法』: “發燒六天分兩波,皮疹常在危險後,血中病毒初五天,疑有登革驗血球。登革治療有撇步,輸液限量不過多,非到必要勿輸血,體液自會重吸收。”。

          2014 年應邀執筆電子版登革教科書(Dengue fever: transmission, diagnosis &

          surveillance", edited by Jamie Whitehorn and Jeremy Farrar, Future Medicine Ltd.

          ISBN: 978-1-78084-384-1),章節主題為”Lessons learned from dengue - Focus

          on Taiwan”,將台灣經驗介紹給全世界相關領域的臨床和研究工作者。

          2011 年創立傳染性疾病及訊息研究中心 (Center of Infectious Disease and Signaling Research),成員涵蓋成大醫學中心臨床與基礎感染症專家。近年與東南亞登革疫區國家:泰國、越南、馬來西亞、新加坡、斯里蘭卡等地醫療與研究機構,建立長期合作模式。

          2017年成大登革研究團隊舉辦新興及再現性感染性疾病工作坊,邀請東南亞登革熱研究學者於成大與會,透過多邊研究成果分享,媒合與會學者與台灣流行病學、重症照護、致病機制、抗病毒藥物及疫苗優化之學者,建立雙向或多向合作,在此概念下成立東南亞登革熱研究委員會,促使東南亞登革熱研究平台成立。

          未來將在已累積的基礎研究成果,以校際與國際宏觀視野,透過深入整合,持續登革病毒臨床、基礎研究及疫苗藥物研發;經由剖析南臺灣登革熱流行病學特點,提升醫療照顧效益,積極培育對登革病毒有研究熱忱新世代人才,運作東亞登革防疫研究平台,為將來登革疫病提供防疫策略和準備。